Publication Date
12-1-2016
Journal
Cerebellum
DOI
10.1007/s12311-015-0724-2
PMID
26439486
PMCID
4846577
PubMedCentral® Full Text Version
Peer Reviewed
Published Open-Access
yes
Keywords
Cerebellum, Progenitors, Purkinje cells, Specification, Differentiation
Abstract
The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.
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