Publication Date

8-1-2023

Journal

Journal of Bone Metabolism

DOI

10.11005/jbm.2023.30.3.231

PMID

37718901

PMCID

PMC10509030

PubMedCentral® Posted Date

8-31-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Dental pulp, Mesenchymal

Abstract

Dental pulp stem cells (DPSCs) have garnered significant interest in dental research for their unique characteristics and potential in tooth development and regeneration. While there were many studies to define their stem cell-like characteristics and osteogenic differentiation functions that are considered ideal candidates for regenerating damaged dental pulp tissue, how endogenous DPSCs respond to dental pulp injury and supply new dentin-forming cells has not been extensively investigated in vivo. Here, we review the recent progress in identity, function, and regulation of endogenous DPSCs and their clinical potential for pulp injury and regeneration. In addition, we discuss current advances in new mouse models, imaging techniques, and its practical uses and limitations in the analysis of DPSCs in pulp injury and regeneration in vivo.

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