Case Report: Contralateral Progression of a Vestibular Schwannoma After Resection in a Patient with Neurofibromatosis Type 2

Authors

Ihika Rampalli
Collin William English
Tyler Lazaro
Benjamin Daniel Lovin
Sungho Lee
Andrew Tsao Huang
Ali Jalali
Kathleen Kelly Gallagher
Jacob J Mandel
Alex Daniel Sweeney
Akash J Patel

Publication Date

3-1-2024

Journal

Neurosurgery Practice

DOI

10.1227/neuprac.0000000000000082

PMID

39957857

PMCID

PMC11783673

PubMedCentral® Posted Date

1-29-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Growth, Resection, Neurofibromatosis 2, Vestibular schwannoma, Case report

Abstract

BACKGROUND AND IMPORTANCE: Bilateral vestibular schwannomas (VS) are a distinctive feature of neurofibromatosis type 2 (NF2) that result in a serious reduction in the quality of life for patients. The growth rates of these schwannomas are variable, and the early detection of increased growth is fundamental for improving outcomes.

CLINICAL PRESENTATION: A 17-year-old man with NF2 and bilateral VS presented with complete right facial paralysis and sudden right hearing loss less than 1 month after resection of a left VS. Imaging revealed rapid growth of the right VS with intratumoral hemorrhage, and the patient underwent urgent surgical resection with some improvement in symptoms.

DISCUSSION: Existing literature indicates a similar phenomenon after a longer post-operative period; however, none have shown such rapid symptomatology. Multiple etiologies were explored for this presentation, including the sudden decompression from the primary resection, paracrine factors, and hypervascularity from prior radiation.

CONCLUSION: VS resection in a patient with NF2 may be followed by rapid growth in the contralateral VS, leading to severe symptom presentation. Patients should be counseled regarding this risk to enable early detection and intervention.