Publication Date
8-1-2024
Journal
Open Forum Infectious Diseases
DOI
10.1093/ofid/ofae443
PMID
39183814
PMCID
PMC11342389
PubMedCentral® Posted Date
8-10-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
adults, children, coronavirus, coronavirus disease 2019, SARS-CoV-2
Abstract
BACKGROUND: Coronavirus disease 2019 (COVID-19) continues to cause hospitalizations and severe disease in children and adults.
METHODS: This study compared the risk factors, symptoms, and outcomes of children and adults hospitalized for COVID-19 from March 2020 to May 2023 across age strata at 5 US sites participating in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence consortium. Eligible patients had an upper respiratory swab that tested positive for severe acute respiratory syndrome coronavirus 2 by nucleic acid amplification. Adjusted odds ratios (aOR) of clinical outcomes were determined for children versus adults, for pediatric age strata compared to adolescents (12-17 years), and for adult age strata compared to young adults (22-49 years).
RESULTS: Of 9101 patients in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence cohort, 1560 were hospitalized for COVID-19 as the primary reason. Compared to adults (22-105 years, n = 675), children (0-21 years, n = 885) were less commonly vaccinated (14.3% vs 34.5%), more commonly infected with the Omicron variant (49.5% vs 26.1%) and had fewer comorbidities (
CONCLUSIONS: Clinical outcomes of COVID-19 differed across pediatric and adult age strata. Adolescents experienced the most severe disease among children, whereas adults 50-64 years experienced the most severe disease among adults.
Included in
Community Health and Preventive Medicine Commons, COVID-19 Commons, Epidemiology Commons, Immunology of Infectious Disease Commons, Immunopathology Commons, Medical Immunology Commons, Pathology Commons, Pediatrics Commons