Maternal Lactobacillus reuteri Supplementation Shifts the Intestinal Microbiome in Mice and Provides Protection From Experimental Colitis in Female Offspring

Authors

Mahesh Krishna
Melinda Engevik
Karen Queliza
Savini Britto
Rajesh Shah
Wenly Ruan
Hongtao Wang
James Versalovic
Richard Kellermayer

Publication Date

2-1-2022

Journal

FASEB BioAdvances

DOI

10.1096/fba.2021-00078

PMID

35141475

PMCID

PMC8814561

PubMedCentral® Posted Date

11-1-2021

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

: inflammatory bowel disease, Lactobacillus, microbiota, pediatric, probiotic, stochastic

Abstract

The purpose of our experiment was to explore how stochastic (inter-individual variation) gut microbiome composition may link to inflammatory bowel disease (IBD) susceptibility and guide the development of a perinatal preventative probiotic. Dextran sodium sulfate (DSS) was introduced to C57BL/BJ mice to induce acute colitis as a model of IBD. Potentially protective bacteria were identified using a discovery-validation cohort approach toward stochastic DSS susceptibility.