Catheter-Based Fetal Cardiac Interventions

Authors

Betul Yilmaz Furtun
Shaine Alaine Morris

Publication Date

5-29-2024

Journal

10.3390/jcdd11060167

DOI

Journal of Cardiovascular Development and Disease

PMID

38921667

PMCID

PMC11204342

PubMedCentral® Posted Date

5-29-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

fetal cardiac intervention, critical congenital heart disease, catheter-based intervention

Abstract

Fetal cardiac intervention (FCI) is an emerging and rapidly advancing group of interventions designed to improve outcomes for fetuses with cardiovascular disease. Currently, FCI is comprised of pharmacologic therapies (e.g., trans-placental antiarrhythmics for fetal arrhythmia), open surgical procedures (e.g., surgical resection of pericardial teratoma), and catheter-based procedures (e.g., fetal aortic valvuloplasty for aortic stenosis). This review focuses on the rationale, criteria for inclusion, technical details, and current outcomes of the three most frequently performed catheter-based FCI procedures: (1) aortic valvuloplasty for critical aortic stenosis (AS) associated with evolving hypoplastic left heart syndrome (HLHS), (2) atrial septal intervention for HLHS with severely restrictive or intact atrial septum (R/IAS), and (3) pulmonary valvuloplasty for pulmonary atresia with intact ventricular septum (PA/IVS).