Publication Date
8-1-2023
Journal
Kidney International Reports
DOI
10.1016/j.ekir.2023.05.026
PMID
37547524
PMCID
PMC10403688
PubMedCentral® Posted Date
6-5-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
acute kidney injury, continuous renal replacement therapy, database, fluid overload, pediatric, WE-ROCK
Abstract
INTRODUCTION: Continuous renal replacement therapy (CRRT) is used for the symptomatic management of acute kidney injury (AKI) and fluid overload (FO). Contemporary reports on pediatric CRRT are small and single center in design. Large international studies evaluating CRRT practice and outcomes are lacking. Herein, we describe the design of a multinational collaborative.
METHODS: The Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) is an international collaborative of pediatric specialists whose mission is to improve short- and long-term outcomes of children treated with CRRT. The aims of this multicenter retrospective study are to describe the epidemiology, liberation patterns, association of fluid balance and timing of CRRT initiation, and CRRT prescription with outcomes.
RESULTS: We included children (
CONCLUSION: The retrospective WE-ROCK study represents the largest international registry of children receiving CRRT for AKI or FO. It will serve as a broad and invaluable resource for the field of pediatric critical care nephrology that will improve our understanding of practice heterogeneity and the association of CRRT with clinical and patient-centered outcomes. This will generate preliminary data for future interventional trials in this area.