Publication Date
3-1-2023
Journal
Annals of Clinical and Translational Neurology
DOI
10.1002/acn3.51714
PMID
36645080
PMCID
PMC10013998
PubMedCentral® Posted Date
1-16-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Child, Interleukin 1 Receptor Antagonist Protein, Retrospective Studies, Cytokines, Electroencephalography, Disease Progression
Abstract
In a retrospective case series of 10 children with cryptogenic FIRES, we sought to describe the early clinical course and potential biomarkers following anakinra initiation. Six children achieved anesthetic withdrawal within 3 weeks of therapy and one in week four. Of the available cEEG (six children), CRP (10 children), and serum cytokine (six children) studies, there were temporal changes in highly epileptiform bursts (observed in three children), CRP, IL-6, and IL-10 levels that might parallel clinical progression. These observations may represent candidate biomarkers for monitoring clinical progression and therapeutic interventions including anakinra, which merits further investigation in future studies.