Publication Date
3-1-2024
Journal
Diabetes/Metabolism Research and Reviews
DOI
10.1002/dmrr.3744
PMID
37888801
PMCID
PMC10939959
PubMedCentral® Posted Date
3-1-2025
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Child, Adolescent, Humans, Young Adult, Adult, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Ethnicity, Cross-Sectional Studies, Prospective Studies, type 1 diabetes, type 2 diabetes, atypical diabetes, classification, diagnosis, pediatric diabetes, diabetes genetic risk score, C-peptide
Abstract
AIMS: Determining diabetes type in children has become increasingly difficult due to an overlap in typical characteristics between type 1 diabetes (T1D) and type 2 diabetes (T2D). The Diabetes Study in Children of Diverse Ethnicity and Race (DISCOVER) programme is a National Institutes of Health (NIH)-supported multicenter, prospective, observational study that enrols children and adolescents with non-secondary diabetes. The primary aim of the study was to develop improved models to differentiate between T1D and T2D in diverse youth.
MATERIALS AND METHODS: The proposed models will evaluate the utility of three existing T1D genetic risk scores in combination with data on islet autoantibodies and other parameters typically available at the time of diabetes onset. Low non-fasting serum C-peptide (
RESULTS: The results are expected to improve the ability to classify diabetes type in a large and growing subset of children who have an unclear form of diabetes at diagnosis.
CONCLUSIONS: Accurate and timely classification of diabetes type will help establish the correct clinical management early in the course of the disease.
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