Publication Date
1-1-2022
Journal
Frontiers in Endocrinology
DOI
10.3389/fendo.2022.900343
PMID
35757406
PMCID
PMC9219591
PubMedCentral® Posted Date
6-9-2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Adult, Amino Acids, Bariatric Surgery, Glycine, Humans, Insulin Resistance, Obesity, Morbid
Abstract
BACKGROUND: Glycine is a dietary non-essential amino acid that is low in obesity and increases following bariatric surgery. However, the exact mechanism responsible remains unclear and it is unknown whether hypoglycinemia is a cause or consequence of insulin resistance.
OBJECTIVE: Using multiple isotopically labeled tracers, we aimed to determine the underlying kinetic changes responsible for hypoglycinemia in obesity by: 1) Comparing glycine kinetics between participants with morbid obesity (BMI ≥ 32.5 kg/m
METHODS: [1,2-
RESULTS: Compared to controls, participants with morbid obesity had significantly lower plasma glycine concentrations at 163 (153-171) vs. 201 (172-227) µmol/L and significantly reduced
CONCLUSION: Hypoglycinemia in participants with morbid obesity was associated with impaired
CLINICAL TRIAL REGISTRATION: [https://tinyurl.com/6wfj7yss], identifier [NCT04660513].
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Biochemical Phenomena, Metabolism, and Nutrition Commons, Digestive System Diseases Commons, Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Gastroenterology Commons, Hepatology Commons, Pediatrics Commons