Evaluation of Stress Ulcer Prophylaxis in Pediatric General Medicine Patients After Transfer From the Intensive Care Unit and at Discharge

Authors

Lamees Loubani
Jenna W Bartlett
Brent Mothner
Rathi Asaithambi
Surin Lee

Publication Date

12-1-2024

Journal

Journal of Pediatric Pharmacology and Therapeutics

DOI

10.5863/1551-6776-29.6.630

PMID

39659854

PMCID

PMC11627567

PubMedCentral® Posted Date

12-9-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

critical care, histamine H2-receptor antagonist, patient discharge, pediatric, proton pump inhibitor, stress ulcer prophylaxis

Abstract

OBJECTIVES: The primary aim of this study was to determine continuation rates of stress ulcer prophylaxis (SUP) upon transfer from a pediatric intensive care unit (PICU) to a general medicine unit and upon hospital discharge. The secondary aim was to identify patient characteristics or concomitant medications that were associated with continuation of SUP at transfer from the PICU.

METHODS: This retrospective chart review included patients who were initiated on acid suppression for SUP in the PICU between June 2021 and May 2022 and subsequently transferred to a general medicine unit prior to discharge. Patients were excluded if they were receiving acid suppressant therapy prior to admission or were started on acid suppressants for an indication other than SUP.

RESULTS: Two hundred three patients (median age, 3.3 years) were included. The rates of SUP continuation at the time of transfer from the PICU to a general medicine unit and at hospital discharge were 61.6% and 9.9%, respectively. Patients continued on SUP at the time of transfer from the PICU were more likely to be prescribed concomitant corticosteroids (p < 0.01), anticoagulants or antiplatelet medications (p < 0.01).

CONCLUSIONS: The continuation of SUP from the PICU to the general medicine unit is common at our institution and calls into question the appropriateness of this practice. Future research is warranted to investigate the appropriateness of the continuation of SUP at transitions of care. Additionally, implementation of institutional protocols standardizing review of SUP may help reduce unnecessary prescribing of acid suppressants in general medicine units and at discharge.