Loss of Growth Differentiation Factor 15 Exacerbates Lung Injury in Neonatal Mice

Authors

Faeq Al-Mudares
Manuel Cantu Gutierrez
Abiud Cantu
Weiwu Jiang
Lihua Wang
Xiaoyu Dong
Bhagavatula Moorthy
Eniko Sajti
Krithika Lingappan

Publication Date

9-1-2023

Journal

American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI

10.1152/ajplung.00086.2023

PMID

37368978

PMCID

PMC10625832

PubMedCentral® Posted Date

6-27-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Animals, Female, Mice, Animals, Newborn, Bronchopulmonary Dysplasia, Growth Differentiation Factor 15, Hyperoxia, Lung, Lung Injury, Mice, Inbred C57BL, bronchopulmonary dysplasia, Gdf15, lung, neonatal, prematurity, sex

Abstract

Growth differentiation factor 15 (GDF15) is a divergent member of the transforming growth factor-β (TGF-β) superfamily, and its expression increases under various stress conditions, including inflammation, hyperoxia, and senescence. GDF15 expression is increased in neonatal murine bronchopulmonary dysplasia (BPD) models, and GDF15 loss exacerbates oxidative stress and decreases cellular viability in vitro. Our overall hypothesis is that the loss of GDF15 will exacerbate hyperoxic lung injury in the neonatal lung in vivo. We exposed neonatal