Publication Date
12-26-2023
Journal
Cell Reports
DOI
10.1016/j.celrep.2023.113471
PMID
37980561
PMCID
PMC10872518
PubMedCentral® Posted Date
2-16-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Mice, Animals, Olfactory Bulb, Smell, Dopamine, Interneurons, gamma-Aminobutyric Acid, Neurotransmitter Agents
Abstract
Co-transmission of multiple neurotransmitters from a single neuron increases the complexity of signaling information within defined neuronal circuits. Superficial short-axon cells in the olfactory bulb release both dopamine and γ-aminobutyric acid (GABA), yet the specific targets of these neurotransmitters and their respective roles in olfaction have remained unknown. Here, we implement intersectional genetics in mice to selectively block GABA or dopamine release from superficial short-axon cells to identify their distinct cellular targets, impact on circuit function, and behavioral contribution of each neurotransmitter toward olfactory behaviors. We provide functional and anatomical evidence for divergent superficial short-axon cell signaling onto downstream neurons to shape patterns of mitral cell firing that contribute to olfactory-related behaviors.