Publication Date

6-11-2024

Journal

Stem Cell Reports

DOI

10.1016/j.stemcr.2024.04.008

PMID

38759644

PMCID

PMC11297560

PubMedCentral® Posted Date

5-16-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, Organoids, Brain, Reproducibility of Results, Prosencephalon

Abstract

Human brain organoid models have emerged as a promising tool for studying human brain development and function. These models preserve human genetics and recapitulate some aspects of human brain development, while facilitating manipulation in an in vitro setting. Despite their potential to transform biology and medicine, concerns persist about their fidelity. To fully harness their potential, it is imperative to establish reliable analytic methods, ensuring rigor and reproducibility. Here, we review current analytical platforms used to characterize human forebrain cortical organoids, highlight challenges, and propose recommendations for future studies to achieve greater precision and uniformity across laboratories.

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