A D2 to D1 Shift in Dopaminergic Inputs to Midbrain 5-HT Neurons Causes Anorexia in Mice

Authors

Xing Cai
Hailan Liu
Bing Feng
Meng Yu
Yang He
Hesong Liu
Chen Liang
Yongjie Yang
Longlong Tu
Nan Zhang
Lina Wang
Na Yin
Junying Han
Zili Yan
Chunmei Wang
Pingwen Xu
Qi Wu
Qingchun Tong
Yanlin He
Yong Xu

Publication Date

5-1-2022

Journal

Nature Neuroscience

DOI

10.1038/s41593-022-01062-0

PMID

35501380

PMCID

PMC9926508

PubMedCentral® Posted Date

2-14-2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Animals, Anorexia, Dopamine, Dopaminergic Neurons, Mesencephalon, Mice, Neurons, Serotonin

Abstract

Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation causing DRD2-dependent inhibition and overeating, while stronger stimulation causing DRD1-dependent activation and anorexia. Furthermore, in the activity-based anorexia (ABA) paradigm, which is a mouse model mimicking some clinical features of human anorexia nervosa (AN), we observed a DRD2 to DRD1 shift of DA neurotransmission on 5-HT

Comments

This article has been corrected. See Nat Neurosci. 2022 Jun 16.