Genome-Wide Association Studies and Fine-Mapping Identify Genomic Loci for N-3 and N-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts

Authors

Chaojie Yang
Jenna Veenstra
Traci M Bartz
Matthew C Pahl
Brian Hallmark
Yii-Der Ida Chen
Jason Westra
Lyn M Steffen
Christopher D Brown
David Siscovick
Michael Y Tsai
Alexis C Wood
Stephen S Rich
Caren E Smith
Timothy D O'Connor
Dariush Mozaffarian
Struan F A Grant
Floyd H Chilton
Nathan L Tintle
Rozenn N Lemaitre
Ani Manichaikul

Publication Date

8-16-2023

Journal

Communications Biology

DOI

10.1038/s42003-023-05219-w

PMID

37587153

PMCID

PMC10432561

PubMedCentral® Posted Date

8-16-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, Genome-Wide Association Study, Fatty Acids, Omega-6, Black or African American, Genomics, Hispanic or Latino, Bestrophins, Genetic association study, Metabolic disorders

Abstract

Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P < 5 × 10