Publication Date
8-16-2023
Journal
Communications Biology
DOI
10.1038/s42003-023-05219-w
PMID
37587153
PMCID
PMC10432561
PubMedCentral® Posted Date
8-16-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Genome-Wide Association Study, Fatty Acids, Omega-6, Black or African American, Genomics, Hispanic or Latino, Bestrophins, Genetic association study, Metabolic disorders
Abstract
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P < 5 × 10
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