Publication Date

10-1-2023

Journal

Pulmonary Circulation

DOI

10.1002/pul2.12299

PMID

37868716

PMCID

PMC10588322

PubMedCentral® Posted Date

10-20-2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

neonatal lung disease & BPD, pediatrics, pulmonary hypertension

Abstract

Patients with bronchopulmonary dysplasia (BPD) have shown clinical improvement after secundum atrial septal defect (ASD) closure. We sought to determine if this post-ASD closure improvement is secondary to the expected course in BPD patients or related to the closure itself. A novel BPD-ASD score was created to assess patients' clinical status (higher score = worse disease) and applied to 10 BPD-ASD inpatients weighing ≤ 10 kg who underwent ASD closure. The score and its subcomponents were retrospectively calculated serially ranging from 8 weeks pre- to 8 weeks post-intervention, and pre- and post-intervention score slopes were created. These slopes were compared using mixed regression modeling with an interaction term. There was a significant difference in pre- versus post-intervention slope with the most score drop the first week post-intervention (-2.1 + /- 0.8,

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