Publication Date
1-1-2023
Journal
Frontiers in Human Neuroscience
DOI
10.3389/fnhum.2023.1291315
PMID
38283094
PMCID
PMC10813208
PubMedCentral® Posted Date
1-12-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
deep brain stimulation (DBS), major depressive disorder (MDD), ventral capsule/ventral striatum, subcallosal cingulate, gamma oscillations, prefrontal networks, stereo-EEG/intracranial recordings
Abstract
Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat a host of neuropsychiatric disorders. However, the detailed neurophysiological effects of stimulation to these hubs are largely unknown. Here, we performed intracranial recordings across prefrontal networks while delivering electrical stimulation to two well-established white matter hubs involved in cognitive regulation and depression: the subcallosal cingulate (SCC) and ventral capsule/ventral striatum (VC/VS). We demonstrate a shared frontotemporal circuit consisting of the ventromedial prefrontal cortex, amygdala, and lateral orbitofrontal cortex where gamma oscillations are differentially modulated by stimulation target. Additionally, we found participant-specific responses to stimulation in the dorsal anterior cingulate cortex and demonstrate the capacity for further tuning of neural activity using current-steered stimulation. Our findings indicate a potential neurophysiological mechanism for the dissociable therapeutic effects seen across the SCC and VC/VS targets for psychiatric neuromodulation and our results lay the groundwork for personalized, network-guided neurostimulation therapy.
Included in
Medical Sciences Commons, Mental and Social Health Commons, Pediatrics Commons, Psychiatry and Psychology Commons, Psychology Commons