Retrospective Analysis of the Impact of High- and Low-Quality Donor Livers for Patients with High-Acuity Illness

Authors

Ron K Varghese
Greta E Handing
Ashley E Montgomery
Abbas A Rana
John A Goss

Publication Date

1-9-2024

Journal

Annals of Transplantation

DOI

10.12659/AOT.941931

PMID

38192097

PMCID

PMC10787593

PubMedCentral® Posted Date

1-9-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Humans, End Stage Liver Disease, Liver Transplantation, Living Donors, Retrospective Studies, Severity of Illness Index, Liver Neoplasms

Abstract

BACKGROUND Patients with high-acuity liver failure have increased access to marginal and split liver options, owing to historically high waitlist mortality rates. While most research states that donor liver quality has no impact on patients with high-acuity illness, there have been inconsistencies in recent research on how liver quality impacts post-transplant outcomes for these patients. We aimed to quantify donor liver quality with various post-transplantation patient outcomes for patients with high-acuity illness. MATERIAL AND METHODS Using the liver donor risk index (LDRI), model for end stage liver disease (MELD), and clinically relevant recipient factors, we used multivariate logistic regression to analyze how donor liver quality affects varying measures of patient outcomes for 9923 high-acuity patients from June 18, 2013, to June 18, 2022. RESULTS Using LDRI, high-quality livers had a significant protective impact on high-acuity patient mortality, compared with low-quality livers (OR=0.695 [0.549, 0.879], P=0.002). High-quality livers also had significant impact on graft survival (OR=0.706 [0.558, 0.894], P=0.004). Two sensitivity patient mortality analyses, excluding patients with status 1A and hepatocellular carcinoma, showed significant protective findings for high-quality livers. High-quality livers had insignificant outcomes on long-term survivor mortality, length of hospitalization, and primary non-function outcomes, compared with low-quality donor livers. CONCLUSIONS While our findings suggest donor quality has an impact on high-acuity patient outcomes, these findings indicate further research is needed in intent-to-treat analysis on clinical offer data to provide a clearer finding of how donor quality affects patients with high-acuity illness.