Publication Date
1-1-2023
Journal
Frontiers in Bioengineering and Biotechnology
DOI
10.3389/fbioe.2023.1061622
PMID
36741765
PMCID
PMC9895798
PubMedCentral® Posted Date
1-20-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
tissue engineering, heart, pump, cardiomycoyte, bioreactor
Abstract
The field of biological pumps is a subset of cardiac tissue engineering and focused on the development of tubular grafts that are designed generate intraluminal pressure. In the simplest embodiment, biological pumps are tubular grafts with contractile cardiomyocytes on the external surface. The rationale for biological pumps is a transition from planar 3D cardiac patches to functional biological pumps, on the way to complete bioartificial hearts. Biological pumps also have applications as a standalone device, for example, to support the Fontan circulation in pediatric patients. In recent years, there has been a lot of progress in the field of biological pumps, with innovative fabrication technologies. Examples include the use of cell sheet engineering, self-organized heart muscle, bioprinting and
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