Publication Date
5-1-2023
Journal
Journal of Surgical Research
DOI
10.1016/j.jss.2022.12.004
PMID
36640607
PMCID
PMC9993344
PubMedCentral® Posted Date
5-1-2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Keywords
Mice, Humans, Animals, Cicatrix, Interleukin-10, Mice, Inbred C57BL, Wound Healing, Skin, Wound Healing, Inflammation, Interleukin-10, Fibrosis, Model, Stenting
Abstract
INTRODUCTION: Interleukin-10 (IL-10) is essential in fetal regenerative wound healing and likewise promotes a regenerative phenotype in adult dermal wounds. However, the role of endogenous IL-10 in postnatal dermal wound healing is not well-established. We sought to determine the function of endogenous IL-10 in murine full thickness excisional wounds that are splinted to prevent contracture and mimic human patterns of wound closure.
METHODS: Full-thickness excisional wounds were made in wildtype (WT) and IL-10
RESULTS: We observed no difference in wound healing rate between WT and IL-10
CONCLUSIONS: These data suggest that endogenous IL-10 expression does not alter closure of full thickness excisional wounds when wound hydration and excessive contraction of murine skin are controlled. However, the loss of IL-10 leads to increased inflammatory cell infiltration and scarring. These new findings suggest that IL-10 contributes to the regulation of inflammation without compromising the healing response. These data combined with previous reports of increased rates of healing in IL-10
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Biological Phenomena, Cell Phenomena, and Immunity Commons, Mental and Social Health Commons, Surgery Commons, Wounds and Injuries Commons