Publication Date
1-1-2024
Journal
International Journal of Nanomedicine
DOI
10.2147/IJN.S455270
PMID
38559447
PMCID
PMC10981898
PubMedCentral® Posted Date
3-27-2024
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Humans, Animals, Rats, Zinc Oxide, Chitosan, Althaea, Interleukin-6, Tumor Necrosis Factor-alpha, Metal Nanoparticles, Anti-Bacterial Agents, Diabetes Mellitus, Wound Healing, Anti-Inflammatory Agents, Inflammation, Flowers, Microbial Sensitivity Tests, Plant Extracts, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction, wound healing, antimicrobial, antioxidant, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, chitosan, wound concentration, wound incision
Abstract
BACKGROUND: Diabetes Mellitus is a multisystem chronic pandemic, wound inflammation, and healing are still major issues for diabetic patients who may suffer from ulcers, gangrene, and other wounds from uncontrolled chronic hyperglycemia.
METHOD AND RESULTS: First, develop eco-friendly green Zinc Oxide Nanoparticles (ZnO-NPs) and incorporate them into a 2% chitosan (CS) gel. In-vitro study performed by UV-visible spectrum analysis showed a sharp peak at 390 nm, and Energy-dispersive X-ray (EDX) spectrometry showed a peak of zinc and oxygen. Besides, Fourier transforms infrared (FTIR) was used to qualitatively validate biosynthesized ZnO-NPs, and transmission electron microscope (TEM) showed spherical nanoparticles with mean sizes of 76 nm and Zeta potential +30mV. The antibacterial potential of A.O.-ZnO-NPs-Cs was examined by the diffusion agar method against Gram-positive (
CONCLUSION: These biocompatible green zinc oxide nanoparticles, by using
Graphical Abstract
Included in
Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Medical Sciences Commons, Mental and Social Health Commons, Surgery Commons, Wounds and Injuries Commons