Publication Date
7-1-2023
Journal
Cureus
DOI
10.7759/cureus.42275
PMID
37605696
PMCID
PMC10440160
PubMedCentral® Posted Date
7-21-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
covid 19, acute disseminated encephalomyelitis (adem), mri flair sequences, atypical covid, rare cause of altered mental status
Abstract
A 42-year-old woman presented with drooling, slurred speech, inability to walk and talk, and a recent positive COVID-19 test. She had two prior hospital admissions within the past week for similar symptoms with inconclusive evaluation. MRI of the brain demonstrated multifocal white matter hyperintense lesions on fluid-attenuated inversion recovery (FLAIR)/diffusion with variable enhancement. These imaging findings have been described in recent literature and are associated with inflammatory demyelinating disease, such as acute disseminated encephalomyelitis. The patient subsequently underwent a brain biopsy with a final diagnosis of inflammatory demyelinating lesion. To our knowledge, this is the first radiologic-pathologic correlation of COVID-19-associated acute disseminated encephalomyelitis.
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