Publication Date

9-30-2024

Journal

Translational Andrology and Urology

DOI

10.21037/tau-24-238

PMID

39434750

PMCID

PMC11491226

PubMedCentral® Posted Date

9-24-2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Clomiphene, enclomiphene, hypogonadism, testosterone, safety

Abstract

BACKGROUND: Both clomiphene citrate and its isomer, enclomiphene, have become widespread within urologic practice; thus, understanding these medications' comparative benefits and risks is crucial for optimizing treatment and providing improved therapeutic options. We sought to investigate the longitudinal benefits and risks associated with enclomiphene, compared to clomiphene, and to provide valuable insights for clinicians when making treatment decisions in the management of hypogonadism.

METHODS: We retrospectively studied patients at our academic center who had been prescribed clomiphene and, later, enclomiphene for hypogonadism. Baseline laboratory values were documented for each patient before being prescribed clomiphene, followed by subsequent values for each variable in the most recent visit before stopping clomiphene and any noted adverse effects experienced during this time. The same process was repeated for enclomiphene, using the clomiphene levels as an updated baseline. Two-tailed

RESULTS: Among 66 patients, enclomiphene exhibited a median testosterone increase of 166 (

CONCLUSIONS: Our findings demonstrate that enclomiphene provides improvement in testosterone levels with a lower rate of documented adverse events. These findings support enclomiphene as a comparable treatment option for hypogonadal men while minimizing the risk of adverse effects. Further research and more extensive studies are warranted to validate these conclusions and explore the additional long-term effects of enclomiphene to guide future patient counseling regarding these medications.

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