Publication Date
1-1-2023
Journal
Research and Reports in Urology
DOI
10.2147/RRU.S278796
PMID
36756281
PMCID
PMC9901485
PubMedCentral® Posted Date
2-2-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Peyronie’s disease, shockwave therapy, platelet rich plasma, Xiaflex, penile curvature, antioxidant therapy
Abstract
The clinical landscape of Peyronie's disease is everchanging. There has been growing interest in non-invasive therapeutic options that could assist patients with achieving a meaningful reduction in penile curvature without surgical intervention. These therapies are wide-ranging in terms of their mechanisms of action, efficacies, and short- and long-term safety profiles. Recently, an abundance of outcomes literature on longstanding and novel non-surgical treatment modalities has been published. For sexual medicine providers hoping to offer patients the most up-to-date and evidence-based treatments for the management of Peyronie's disease, it can be challenging to gain a thorough understanding of this body of literature. In this clinical management review, the workup and current theories on the pathophysiology of Peyronie's disease are reviewed, and the most recent outcomes data on the currently available non-surgical treatment modalities are presented. With an accurate understanding of the current landscape of Peyronie's disease treatment, sexual health providers will be able to better evaluate and engage in evidence-based shared decision-making with their patients.