Publication Date
6-12-2023
Journal
BMJ Open
DOI
10.1136/bmjopen-2022-071311
PMID
37308268
PMCID
PMC10277034
PubMedCentral® Posted Date
6-12-2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Keywords
Adult, Humans, Albuterol, Ethics Committees, Research, Glucose, Hyperkalemia, Insulin, Clinical Trials, Phase IV as Topic, Randomized Controlled Trials as Topic, Multicenter Studies as Topic
Abstract
INTRODUCTION: Hyperkalaemia is common, life-threatening and often requires emergency department (ED) management; however, no standardised ED treatment protocol exists. Common treatments transiently reducing serum potassium (K
METHODS AND ANALYSIS: PLATINUM is a Phase 4, multicentre, randomised, double-blind, placebo-controlled study in participants who present to the ED at approximately 30 US sites. Approximately 300 adult participants with hyperkalaemia (K
ETHICS AND DISSEMINATION: A central Institutional Review Board (IRB) and Ethics Committee provided protocol approval (#20201569), with subsequent approval by local IRBs at each site, and participants will provide written consent. Primary results will be published in peer-reviewed manuscripts promptly following study completion.