Antidiabetic medication utilization patterns and related levels of glucose control among Mexican Americans in Starr County Texas - A cross sectional secondary analysis
Objective: To characterize the types and patterns of antidiabetic medication use among Mexican American individuals with type 2 diabetes and to assess any differences in glycemic control with use of various antidiabetic agents. Methods: A cross sectional secondary analysis was conducted on data obtained from 482 participants with type 2 diabetes in Starr County, Texas between 2010 and 2014. Descriptive statistics of antidiabetic medication use and variables such as age, gender, fasting blood glucose, HbA1C, presence of hypertension, duration of diabetes, blood pressure, BMI and number of antihypertensive medications were assessed. ANCOVA analyses to identify any differences in glycemic control among those taking different categories of antidiabetic agents were also done. Results: Only 21.8% of the study population had adequate glycemic control. About a third of the population used 2 antidiabetic medications. Almost a quarter of the study participants were taking combination therapy when compared to 14% in the general population. The level of glycemic control was worse among those taking a combination of oral antidiabetic agents and insulin. Results from ANCOVA analyses showed that there is a statistically significant difference in the mean levels of glycemic control among those taking different categories of antidiabetic agents. A wide array of antidiabetic medication combinations were utilized in the study population. Conclusions: The antidiabetic medications used were comparable to those used in the general population though the population under study had poorer glycemic control than the general population. There are also differences in the level of glycemic control achieved with the different antidiabetic agents. Increased utilization of metformin with a non sulfonylurea oral medication or an insulin rather than just metformin and sulfonylurea combination should be warranted in the population to achieve better control of hyperglycemia. As this is a high risk population, further research looking at therapeutic measures for optimal glycemic control should be undertaken.
Endocrinology|Medicine|Public health|Hispanic American studies|Epidemiology
Muthumarthandarajan, Boomadevi, "Antidiabetic medication utilization patterns and related levels of glucose control among Mexican Americans in Starr County Texas - A cross sectional secondary analysis" (2015). Texas Medical Center Dissertations (via ProQuest). AAI10027731.