Association between vaccinations and childhood rhabdomyosarcoma in Texas
Childhood rhabdomyosarcoma (RMS) is a rare malignant tumor of the developing skeletal muscle for which few susceptibility factors have been found. Previous research from our group has shown that childhood vaccinations may have a protective role in childhood RMS. To explore this association in Texas during a more recent time period, we used data from the Texas Cancer Registry and the Department of State Health Statistics to compare vaccination rates and childhood RMS at a county and public health region level. Cases were diagnosed between 1995–2011 and were frequency matched to controls on sex and year of birth. For the final analysis, a total of n=139 cases and n=2085 controls were examined. Vaccine rates were assessed categorically as ≤50 th percentile (reference) and >50th percentile. Multi-level logistic regression models were used to calculate an odds ratio (OR) and 95% confidence interval (CI) for each exposure, adjusted for age, birth year, maternal ethnicity, maternal age at birth and an area-based poverty measure. We evaluated vaccination rates and childhood RMS at both a county and public health region level. There was no evidence that completion of individual vaccines or vaccination series were associated with childhood RMS.
Sankaran, Hari, "Association between vaccinations and childhood rhabdomyosarcoma in Texas" (2016). Texas Medical Center Dissertations (via ProQuest). AAI10126780.