Characterization of Staphylococcus aureus isolates associated with pediatric carriage in Houston, Texas

Jesse W Dunkle, The University of Texas School of Public Health


Infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) have been of great concern in hospitals due the difficulty in treating virulent, antibiotic resistant microorganisms in sensitive populations including children, the elderly, and immunocomprimised individuals. Since the late 1990's, MRSA infections have become a problem in the general community, and the strains of S. aureus that cause infections in the community are known to be genetically different than the hospital acquired strains. Community-acquired strains tend to be more virulent, affecting even relatively healthy individuals, and disease presentation tends to be more diverse than diseases observed in patients suffering from hospital-acquired strains. From the year 2000 to the present, there has been a significant increase in community-acquired infections in children, a population already particularly sensitive to S. aureus infection. Genotyping the strains of CA-MRSA circulating in the pediatric population is an important step in developing better antibiotic treatment strategies. Additionally, determining the carriage status of individuals in this population and comparing these data with strain genotypes will also be valuable in establishing prevention and control practices.

Subject Area


Recommended Citation

Dunkle, Jesse W, "Characterization of Staphylococcus aureus isolates associated with pediatric carriage in Houston, Texas" (2009). Texas Medical Center Dissertations (via ProQuest). AAI1462295.