A systematic review supporting genetic susceptibility to Clostridium difficile infection

Bingjie Li, The University of Texas School of Public Health


Clostridium difficile associated diarrhea (CDAD) is one of the most common hospital- and antibiotic-acquired infectious diseases. Every year, 300 000 to 3 000 000 CDAD cases appear in the United States and the number of cases has increased recently. People are not equally likely to acquire this infection since the susceptibility to infectious diseases arises from the complicated interaction between the microbe, the host and its resistance factors and the environment. More articles are showing important host genetic factors included in the susceptibility to enteric pathogens infection including C. difficile as well as other infectious diseases. Single-nucleotide polymorphisms have been found in various genes, such as IL-8, IL-10, LTFE, OPG and CD14. These findings imply that certain genotypes may be associated with different susceptibility to infection. In this systematic review, findings in the literature are collected and analyzed together. Current research progress and gaps in the literature are identified in order to provide evidence for future research.

Subject Area


Recommended Citation

Li, Bingjie, "A systematic review supporting genetic susceptibility to Clostridium difficile infection" (2013). Texas Medical Center Dissertations (via ProQuest). AAI1549832.