The association between chronic kidney disease and a history of West Nile virus infection
Introduction: Previous animal and human studies have shown that a history of West Nile virus (WNV) infection may be a risk factor for subsequent development of Chronic Kidney Disease (CKD). However, no study to date has compared the prevalence of CKD in a group of WNV positive subjects to a group of matched WNV negative subjects. Methods: The prevalence of CKD and associated risk factors were compared between a cohort of 89 subjects with a history of WNV infection and a group of 89 age, gender, and ethnicity matched subjects with no history of WNV infection. CKD was defined by the Kidney Disease Outcomes Quality Initiative (KDOQI) criteria based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and other urinary abnormalities. Results: There was no statistically significant difference in prevalence of CKD in subjects with a history of WNV compared to age, gender, and race matched WNV negative subjects (PR: 0.74 95% CI:0.48-1.15). The prevalence of CKD was 26% in WNV positive subjects and 35% in WNV negative subjects. There were no statistically significant differences in risk factors for other known risk factors for CKD such as diabetes and hypertension. Discussion: This study does not support a general association between WNV infection and subsequent development of CKD. Future studies should focus on specific types of WNV disease history, particularly among patients with a history of neuroinvasive disease.
Philpott, David, "The association between chronic kidney disease and a history of West Nile virus infection" (2014). Texas Medical Center Dissertations (via ProQuest). AAI1568975.