Genes associated with temporomandibular joint disorders (TMDs): A systematic review

Dhruvee Sangani, The University of Texas School of Public Health


Context: The association of genes with temporomandibular joint (TMJ) disorders (TMDs) has not been well established. Objective: To determine the association of genes and gene mutations on TMDs in humans and animals. Data Sources: Medline (Ovid), EMBASE (Ovid) and PubMed (NLM) were searched for articles using the terms for the concepts of TMDs and genes/genetic mutations. Publication dates for articles were limited to 2000-2015; only articles published in English were reviewed. Additional studies were identified by searching bibliographies of highly relevant articles as well as using Scopus (Elsevier) to track cited articles. Lastly, authors of relevant studies were further searched in the literature databases to ensure that all articles related to each study are retrieved. Study Selection: Only studies that met the eligibility criteria were included for review. An inclusion and exclusion criteria was established. Data Extraction: A codebook was developed to extract data from each article. Solely I did the data extraction. Results: The search strategy identified 31 articles obtained from thorough searches in Medline (Ovid), EMBASE (Ovid) and PubMed (NLM). Most of the research in the articles included was done on mice. Outcomes of the studies included in this review were measured by using personal assessment of whether the results of the studies were statistically significant or not. Total 112 genes were identified to be associated with TMDs by this review to be statistically significant with TMDs specifically but not limited to ankylosis, internal derangement, syngnathia, osteoporosis, and dysplasia. Conclusions: Overall, there is insufficient research and evidence to determine if genes are associated with TMDs. This review provides a list of few genes associated with TMDs that are currently documented in scientific literature.

Subject Area

Genetics|Health sciences|Dentistry

Recommended Citation

Sangani, Dhruvee, "Genes associated with temporomandibular joint disorders (TMDs): A systematic review" (2015). Texas Medical Center Dissertations (via ProQuest). AAI1597548.