Metabolic syndrome and erectile dysfunction in US men

Christine Yang, The University of Texas School of Public Health


Erectile dysfunction (ED) is a prevalent condition among adult men and an important medical issue confronting the aging United States (US) population. Risk factors for ED include the metabolic syndrome (MetS) and many of its components, a condition with rising prevalence worldwide. Several population-based cross-sectional studies conducted in Europe, East Asia and the United States found positive associations between MetS and ED. However, these previous studies have not utilized the most recent definition of MetS, the Joint Scientific Statement of 2009, which uses race- and ethnic-specific measurements. We conducted an analysis using the 2001 to 2002 and 2003 to 2004 cycles of the population-based National Health and Nutrition Examination Survey (NHANES) to characterize the association between MetS and ED. We used multiple logistic regression models to investigate the association while controlling for the risk factors age, race/ethnicity, smoking, physical activity, education, marital status and BMI, and stratifying for the potential effect modifiers race/ethnicity and prescription medication use. We found that MetS was positively associated with ED (POR = 1.64, 95% CI: [1.27-2.11]). The association did not vary by race/ethnicity, hypertension medication use, or diabetes medication use. The association varied significantly by lipid medication use (lipid medication use POR = 1.94, 95% CI: [1.11-3.38]; no lipid medication use POR = 1.35, 95% CI: [0.95-1.93]), and by statin medication use (statin use POR = 2.29, 95% CI: [1.26-4.16]; no statin use POR = 1.29, 95% CI: [0.92-1.81]). The results from this study have the potential to allow clinicians to provide better preventative medication to individuals with MetS and to better understand the relationship between these two conditions in the US population.

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Recommended Citation

Yang, Christine, "Metabolic syndrome and erectile dysfunction in US men" (2015). Texas Medical Center Dissertations (via ProQuest). AAI1598403.