A comparative study of Theil regression and t-test: A case of CCTRN TIME study

Wei Zou, The University of Texas School of Public Health


Acute myocardial infarction (AMI), the medical term for a heart attack, is a leading cause of morbidity and mortality worldwide. In this study, we used Theil regression method (a non-parametric method) to evaluate the effect of bone marrow mononuclear cells (BMMNCs) treatment on heart attack of the CCTRN TIME trial. Six of total ten slopes estimated by the Theil regression for treatment group or placebo group are consistent with the mean primary or secondary outcome difference between baseline and 6 month. And all p-values from Sen-Adichie test are similar as the traditional t-test that the outcome difference between the BMMNCs treatment group and placebo group is not statistically significant. This is consistent with the previous CCTRN TIME studies that BMMNCs are not significantly effective in improving heart left ventricular function as observed 6 months after cell administration. However, recent and ongoing long-term follow up studies of these patients and improvement of the study design may still reveal the effect of cell therapy in cardiovascular disease.

Subject Area

Statistics|Public health

Recommended Citation

Zou, Wei, "A comparative study of Theil regression and t-test: A case of CCTRN TIME study" (2015). Texas Medical Center Dissertations (via ProQuest). AAI1598405.