IL -10 polymorphisms in patients with HIV and HIV/HCV co-infection
For successful long-term survival with chronic disease, like with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV), the immune system must balance between pathogen clearance and inflammatory response which is primarily mediated by cytokines. Interleukin-10 has been noted in both HIV and HCV disease progression. Three previously studied SNPs, IL10-592, IL10-1082 and IL10-819 SNPs were analyzed to look for association with HIV and HIV/HCV disease susceptibility and HIV disease progression. Healthy controls were compared to HIV infected cases to identify an increased prevalence in variants of IL-10. HIV infected patients were stratified by nadir CD4 cell counts and zenith HIV RNA levels as surrogate markers of HIV disease progression. The secondary aims focused on the IL-10 SNPs in HIV/HCV co-infected patients. Patients were also stratified by cleared or active HCV RNA status. We found that although the prevalence of the SNPs was similar to previously published data, there was no significant difference in the prevalence of IL10-592, the IL10-1082, or the IL10-819 SNPs between patients with HIV infection and healthy controls. When stratified by race, African Americans showed a significant association between the 1082-G allele and having a low HIVRNA zenith (OR=0.46, p=0.03). The IL10-592-A SNP trended toward significance suggesting that Hispanic carriers of the SNP were half as likely to be HIV/HCV co-infected when compared to HIV mono-infected patients (OR=0.51, p=0.06). A logistic regression showed the IL10-592 and IL10-1082 SNPs were not significantly associated with being co-infected (IL10-592 p=0.38, IL10-1082 p=0.51). Also there was no significant association between HIV/HCV co-infection and having the 1082-592 A-A, A-C, or G-C haplotypes. Trends in the data suggested that the IL10-592A/A genotype may decrease the odds of being HIV/HCV co-infected when stratified by race, and the 1082-G allele was positively associated with low HIVRNA zenith level in African Americans, a potentially important finding. Furthermore, this is, perhaps, the first study looking specifically at IL-10 SNPs in HIV/HCV co-infected patients and the first to investigate the polymorphisms in terms of surrogate markers of HIV disease progression.
Bull, Lara M, "IL -10 polymorphisms in patients with HIV and HIV/HCV co-infection" (2007). Texas Medical Center Dissertations (via ProQuest). AAI3290036.