CIRCADIAN RHYTHM IN THE BIOAVAILABILITY OF ORALLY ADMINISTERED THEOPHYLLINE
The effect of time (i.e., biologic time structure) of drug administration on the bioavailability of theophylline was investigated in man after both a single dosage as well as after repeated, or chronic, drug administrations. Preliminary laboratory investigations on Balb-C mice showed the toxic
KYLE, GLENNA MAXEY, "CIRCADIAN RHYTHM IN THE BIOAVAILABILITY OF ORALLY ADMINISTERED THEOPHYLLINE" (1979). Texas Medical Center Dissertations (via ProQuest). AAI8112521.