DigitalCommons@TMC

TARGETING METABOLIC ALTERATIONS ASSOCIATED WITH SMOOTH MUSCLE α-ACTIN PATHOGENIC VARIANT ATTENUATES MOYAMOYA-LIKE CEREBROVASCULAR DISEASE, Anita Kaw
Dissertations and Theses (Open Access)

Adipocytes and Innate Immunity in Systemic Sclerosis, Nancy Wareing
Dissertations and Theses (Open Access)

HYPOXIA ACTIVATED PRODRUG AND ANTI-ANGIOGENIC THERAPY COOPERATE TO TREAT PANCREATIC CANCER BUT ELICIT IMMUNE SUPPRESSIVE G-MDSC INFILTRATION, Arthur Liu
Dissertations and Theses (Open Access)

Understanding and Targeting the Immunosuppressive Tumor Microenvironment, Li Cai, Li Cai
Dissertations and Theses (Open Access)

The Role of the Hypoxia-Inducible Factor 2 in Pancreatic Cancer: Mechanisms of Tumor Immunosuppression and Intestinal Radioprotection, Carolina Garcia Garcia
Dissertations and Theses (Open Access)

A MICROFLUIDICS-BASED APPROACH FOR ISOLATION OF ANTIGEN-SPECIFIC CD8+ T CELLS, Meredith Frank
Dissertations and Theses (Open Access)

DEVELOPMENT OF THE ARK ASSAY FOR QUANTITATING DNA- PROTEIN CROSSLINK ACCUMULATION AND FANCONI ANEMIA PATHWAY INVOLVEMENT IN THE REPAIR PROCESS, Naeh Klages-Mundt
Dissertations and Theses (Open Access)

4D EX VIVO CRISPR/CAS9 WHOLE-GENOME SCREEN TO IDENTIFY GENES REGULATING LUNG CANCER METASTASIS, Alexandria Plumer
Dissertations and Theses (Open Access)

Unveiling global roles of G-quadruplexes and G4-22 in human genetics, Ruth Barros De Paula
Dissertations and Theses (Open Access)

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Response to Immune Checkpoint Blockade, Alexandria Cogdill
Dissertations and Theses (Open Access)

Assessing the Outcomes of Blocking CCL2-CCR2 Signaling Axis on Breast Cancer Brain Metastasis, Yutao Qi
Dissertations and Theses (Open Access)

A CONTEXT-FORWARD IN VIVO FUNCTIONAL GENOMICS PLATFORM FOR TARGET DISCOVERY AND ESTABLISHING VULNERABILITY CONTEXT IN PANCREATIC CANCER, Johnathon Rose, Johnathon Lynn Rose
Dissertations and Theses (Open Access)

Modulating Avidity of h8F4-CAR by Regulation of Expression via Codon Modification, Rolando Vedia
Dissertations and Theses (Open Access)

ALTERNATIVE POLYADENYLATION MODULATES EXPRESSION OF PRO-FIBROTIC PROTEINS AND CONTRIBUTES TO LUNG FIBROSIS, Junsuk Ko
Dissertations and Theses (Open Access)

UNDERSTANDING INTERCELLULAR SIGNALING DURING LUNG INJURY-REPAIR, Margo Patricia Cain
Dissertations and Theses (Open Access)

IPSC BASED GENE CORRECTION AND DISEASE MODEL OF A NEW CLASS OF LGMD DUE TO POGLUT1 MUTATION, Jose Ortiz-Vitali
Dissertations and Theses (Open Access)

Rejuvenation of the Epigenetic Landscape of the Aged Brain Through Manipulation of Circulating Factors, Edward Koellhoffer
Dissertations and Theses (Open Access)

Thiol-based Misfolding: Linking Redox Balance to Cytosolic Proteostasis, Ford Amy
Dissertations and Theses (Open Access)

The Role of Tumor Suppressor DEAR1 in the Acquisition of Mammary Stem/Progenitor Cell Properties, Uyen Le
Dissertations and Theses (Open Access)

Behavioral Insights into Nociceptor Function: A Systematic Approach to Understanding Postsurgical and Neuropathic Pain Mechanisms in Rats, Max Odem
Dissertations and Theses (Open Access)

IDENTIFICATION AND UTILITY OF DNA IN EXOSOMES, Paul Kurywchak
Dissertations and Theses (Open Access)

CHARACTERIZATION OF NOTCH1 AND PI3K-PTEN-AKT/mTOR PATHWAY INTERACTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA, Kyriante' Henry
Dissertations and Theses (Open Access)

Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer, Angie M. Torres-Adorno
Dissertations and Theses (Open Access)

THE ROLE OF THE EPITHELIAL-TO-MESENCHYMAL TRANSITION (EMT) IN LUNG CANCER PROGRESSION, David H. Peng
Dissertations and Theses (Open Access)

INVESTIGATION OF THE ROLES OF ASF1 AND CAF-1-MEDIATED CHROMATIN ASSEMBLY IN THE HUMAN DNA DAMAGE RESPONSE, Ting-Hsiang Huang
Dissertations and Theses (Open Access)

Evaluating the impact of post-translational modifications by the secreted zinc metalloprotease, GelE, on the major autolysin of E. faecalis, AtlA, and a stress-induced protein, SalB, Emily K. Stinemetz
Dissertations and Theses (Open Access)

The Role of the DIRAS Family Members in Regulating Ras Function, Cancer Growth and Autophagy, Margie Nicole Sutton
Dissertations and Theses (Open Access)

REGULATION OF BREAST CANCER INITIATION AND PROGRESSION BY 14-3-3ZETA, Chia-Chi Chang
Dissertations and Theses (Open Access)

INSIGHTS INTO DETERMINANTS THAT CONTRIBUTE TO COLONIZATION, VIRULENCE AND ANTIBIOTIC RESISTANCE IN ENTEROCOCCI, Maria Camila Montealegre
Dissertations and Theses (Open Access)

PLASMACYTOID DENDRITIC CELL-MEDIATED HUMORAL AUTOIMMUNITY, Stephanie M. Dorta-Estremera Ph.D.
Dissertations and Theses (Open Access)

Normal Glycolytic Enzyme Activity is Critical for Hypoxia Inducible Factor-1a Activity and Provides Novel Targets for Inhibiting Tumor Growth, Geoffrey Grandjean PhD
Dissertations and Theses (Open Access)

MULTILEVEL DEREGULATION OF SURVIVAL MECHANISMS IN NPM-ALK+ T-CELL LYMPHOMA, Deeksha Vishwamitra
Dissertations and Theses (Open Access)

TARGETING COX-2 AND RANK IN AGGRESSIVE BREAST CANCERS: INFLAMMATORY BREAST CANCER AND TRIPLE-NEGATIVE BREAST CANCER, Monica E. Reyes
Dissertations and Theses (Open Access)

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer, Umadevi Thirumurthi
Dissertations and Theses (Open Access)

Sustained adrenergic signaling promotes cervical cancer progression, Nouara C. Sadaoui
Dissertations and Theses (Open Access)

Novel Posttranslational Modification in LKB1 Activation and Function, Szu-Wei Lee
Dissertations and Theses (Open Access)

TARGETING COX-2 AND RANK IN AGGRESSIVE BREAST CANCERS: INFLAMMATORY BREAST CANCER AND TRIPLE-NEGATIVE BREAST CANCER, Monica Elizabeth Reyes
Dissertations and Theses (Open Access)

REACTIVE OXYGEN SPECIES AND P21 WAF1/CIP1 ARE BOTH ESSENTIAL FOR, Alison Fitzgerald
Dissertations and Theses (Open Access)

ENERGY STRESS CAUSES CHAPERONES TO ASSEMBLE INTO CYTOPLASMIC COMPLEXES, Kimberly J. Cope
Dissertations and Theses (Open Access)

PANCREATIC RIBONUCLEASE FUNCTIONS AS AN EPIDERMAL GROWTH FACTOR RECEPTOR LIGAND INDEPENDENTLY OF ITS ENZYME ACTIVITY AND CONTRIBUTES TO CETUXIMAB RESISTANCE, Heng-Huan Lee
Dissertations and Theses (Open Access)

Strategies to sensitize bladder cancer cells to small molecule inhibitors targeting the PI3K pathway, Giovanni Nitti
Dissertations and Theses (Open Access)

TARGETING THE MDM2-P53 AXIS FOR THE TREATMENT OF DEDIFFERENTIATED LIPOSARCOMA, Katelynn Bill
Dissertations and Theses (Open Access)

PI3K- and mTOR-dependent mechanisms of lapatinib resistance and resulting therapeutic opportunities, Samuel Brady
Dissertations and Theses (Open Access)

DEVELOPMENT OF CHIMERIC TYPE IV SECRETION SYSTEMS FOR TRANSFER OF HETEROLOGOUS SUBSTRATES ACROSS THE GRAM-NEGATIVE CELL ENVELOPE, Trista M. Berry
Dissertations and Theses (Open Access)

Gain-of-function Mouse Models to Investigate Biological Roles of PRMT6, Alessandra Di Lorenzo
Dissertations and Theses (Open Access)

DEVELOPMENTAL AND MOLECULAR FUNCTIONS OF PLAKOPHILIN-3, William A. Munoz
Dissertations and Theses (Open Access)

Characterization of Jak, STAT, and Src interactions in Head and Neck Squamous Cell Carcinoma, Reshma Jaseja, Reshma Jaseja
Dissertations and Theses (Open Access)

CHARACTERIZATION OF TCL1-Tg:P53-/- MICE THAT RESEMBLE HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA WITH 17P-DELETION, Jinyun Liu
Dissertations and Theses (Open Access)

Targeting AKT/mTOR Signaling Pathways During Murine Skin Tumor Promotion and the Impact of Dietary Energy Balance Manipulation, Laura A. Checkley
Dissertations and Theses (Open Access)

CHEMOSENSITIZATION OF HEPATOCELLULAR CARCINOMA TO GEMCITABINE BY NON-INVASIVE RADIOFREQUENCY FIELD-INDUCED HYPERTHERMIA, Mustafa Raoof
Dissertations and Theses (Open Access)

LMW-E MEDIATES MAMMARY TUMORIGENESIS BY DEREGULATING ACINAR MORPHOGENESIS & GENERATING CANCER STEM CELLS, MyLinh T. Duong
Dissertations and Theses (Open Access)

Increased geranylgeranylated K-Ras contributes to antineoplastic effects of farnesyltransferase inhibitors., Mandy A. Hall
Dissertations and Theses (Open Access)

NOVEL MECHANISMS OF ANTIGEN PROCESSING THAT ENHANCE BCG VACCINE EFFICACY, Christopher R. Singh
Dissertations and Theses (Open Access)

Significance of Increased Tissue Transglutaminase in Hormone Refractory Prostate Cancer, Amy L. Han
Dissertations and Theses (Open Access)

The Role of the Androgen Receptor Cofactor p44/WDR77 in Astrocyte Activation, Bryce H. Vincent
Dissertations and Theses (Open Access)

Stromal derived growth factor alpha (SDF-1α) induces the differentiation of bone marrow progenitor cells (BMCs) into pericytes by regulating platelet derived growth factor B (PDGF-B) transcription, Randala Hamdan
Dissertations and Theses (Open Access)

DEFINING THE ROLE OF EGFR ACETYLATION IN CELLULAR PROCESSES: CLINICAL IMPLICATIONS, Hui Song
Dissertations and Theses (Open Access)

ELUCIDATING FUNCTIONAL ROLES FOR MYOGENIN IN ADULT SKELETAL MUSCLE METABOLISM, EXERCISE CAPACITY, AND REGENERATION, Jesse Flynn
Dissertations and Theses (Open Access)

Dynamic Remodeling of the Stressed Heart: Role of Protein Degradation Pathways, Deborah Vela
Dissertations and Theses (Open Access)

Understanding acquired resistance to Lapatinib in breast cancer cells, Jen-Te Tseng
Dissertations and Theses (Open Access)

MODELING SPORADIC TUMOR FORMATION DRIVEN BY TELOMERE DYSFUNCTION IN THE GASTROINTESTINAL TRACT, Suzanne S. Chan
Dissertations and Theses (Open Access)

A METAGENOMIC STUDY OF THE TICK MIDGUT, Daniel T. Yuan
Dissertations and Theses (Open Access)

DOUBLE-STRAND BREAK REPAIR PATHWAYS IN DNA STRUCTURE-INDUCED GENETIC INSTABILITY, Diem T. Kha
Dissertations and Theses (Open Access)

NEW TARGET GENES FOR TUMOR SUPPRESSORS p53 AND p73 IN REGENERATING LIVER, Svitlana M. Kurinna
Dissertations and Theses (Open Access)