Signaling Mechanisms Underlying Activity-Dependent Integration of Adult-Born Neurons in the Mouse Olfactory Bulb

Authors

Suyang Bao
Juan M Romero
Benjamin D W Belfort
Benjamin R Arenkiel

Publication Date

4-1-2024

Journal

Genesis

DOI

10.1002/dvg.23595

PMID

38553878

PMCID

PMC10987073

PubMedCentral® Posted Date

4-1-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Mice, Animals, Olfactory Bulb, Neurons, Neurogenesis, Brain, adult-born neuron, neurogenesis, activity-dependent, olfactory bulb, plasticity, circuit integration, neuropeptide

Abstract

Adult neurogenesis has fascinated the field of neuroscience for decades given the prospects of harnessing mechanisms that facilitate the rewiring and/or replacement of adult brain tissue. The subgranular zone of the hippocampus and the subventricular zone of the lateral ventricle are the two main areas in the brain that exhibit ongoing neurogenesis. Of these, adult-born neurons within the olfactory bulb have proven to be a powerful model for studying circuit plasticity, providing a broad and accessible avenue into neuron development, migration, and continued circuit integration within adult brain tissue. This review focuses on some of the recognized molecular and signaling mechanisms underlying activity-dependent adult-born neuron development. Notably, olfactory activity and behavioral states contribute to adult-born neuron plasticity through sensory and centrifugal inputs, in which calcium-dependent transcriptional programs, local translation, and neuropeptide signaling play important roles. This review also highlights areas of needed continued investigation to better understand the remarkable phenomenon of adult-born neuron integration.