Acute and Chronic Kidney Injury During Therapy for Pediatric Acute Leukemia: A Report From the Leukemia Electronic Abstraction of Records Network (LEARN)

Authors

Wendy Hsiao
Yimei Li
Kelly Getz
Lusha Cao
Edward Krause
Mark Ramos
Judy Lee
Maria Monica Gramatges
Karen R Rabin
Michael E Scheurer
Richard Aplenc
Michelle Denburg
Tamara P Miller

Publication Date

12-1-2023

Journal

Pediatric Blood & Cancer

DOI

10.1002/pbc.30696

PMID

37776085

PMCID

PMC10793071

PubMedCentral® Posted Date

1-17-2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Child, Humans, Retrospective Studies, Hospital Mortality, Kidney, Acute Kidney Injury, Renal Insufficiency, Chronic, Leukemia, Myeloid, Acute, Electronics, Risk Factors, acute kidney disease, acute kidney injury, acute lymphoblastic leukemia, acute myeloid leukemia, chronic kidney disease

Abstract

Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.