Profound and Redundant Functions of Arcuate Neurons in Obesity Development

Authors

Canjun Zhu
Zhiying Jiang
Yuanzhong Xu
Zhao-Lin Cai
Qingyan Jiang
Yong Xu
Mingshan Xue
Benjamin R Arenkiel
Qi Wu
Gang Shu
Qingchun Tong

Publication Date

8-1-2020

Journal

Nature Metabolism

DOI

10.1038/s42255-020-0229-2

PMID

32719538

PMCID

PMC7687864

PubMedCentral® Posted Date

1-27-2021

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

Keywords

Aging, Agouti-Related Protein, Animals, Arcuate Nucleus of Hypothalamus, Body Weight, Eating, Energy Metabolism, Female, Leptin, Male, Mice, Mice, Obese, Neurons, Obesity, Weight Gain, gamma-Aminobutyric Acid

Abstract

The current obesity epidemic faces a lack of mechanistic insights. It is known that the acute activity changes of a growing number of brain neurons rapidly alter feeding behaviour; however, how these changes translate to obesity development and the fundamental mechanism underlying brain neurons in controlling body weight remain elusive. Here, we show that chronic activation of hypothalamic arcuate GABAergic (GABA