Associations Between Lipoprotein Subfractions and Area and Density of Abdominal Muscle and Intermuscular Adipose Tissue: The Multi-Ethnic Study of Atherosclerosis

Authors

Megan M Marron
Matthew Allison
Alka M Kanaya
Britta Larsen
Alexis C Wood
David Herrington
Philip Greenland
Iva Miljkovic

Publication Date

1-1-2021

Journal

Frontiers in Physiology

DOI

10.3389/fphys.2021.713048

PMID

34646150

PMCID

PMC8502976

PubMedCentral® Posted Date

9-27-2021

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

skeletal muscle, myosteatosis, lipids, metabolism, lipidomics, lipoproteins

Abstract

Skeletal muscle quantity and quality decrease with older age, which is partly attributed to ectopic fat infiltration and has negative metabolic consequences. To inform efforts to preserve skeletal muscle with aging, a better understanding of biologic correlates of quantity and quality of muscle and intermuscular adipose tissue (IMAT) is needed. We used targeted lipidomics of lipoprotein subfractions among 947 Multi-Ethnic Study of Atherosclerosis participants to provide a detailed metabolic characterization of area and density of abdominal muscle and IMAT. Serum lipoprotein subfractions were measured at the first visit using 1H-Nuclear Magnetic Resonance spectroscopy. Muscle and IMAT area (cm