The Shape of the Oral Glucose Tolerance Test-Glucose Response Curve in Islet Cell Antibody-Positive vs. -Negative Obese Youth Clinically Diagnosed with Type 2 Diabetes

Authors

Joon Young Kim
Hala Tfayli
Fida Bacha
Silva Arslanian

Publication Date

6-30-2021

Journal

Journal of Obesity & Metabolic Syndrome

DOI

10.7570/jomes20088

PMID

34059560

PMCID

PMC8277592

PubMedCentral® Posted Date

6-1-2021

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

Keywords

Oral glucose tolerance test, Glucose intolerance, Insulin resistance, Insulin secretion, Type 2 diabetes mellitus, Obesity, Adolescent

Abstract

BACKGROUND: The oral glucose tolerance test (OGTT)-glucose response curves (GRCs; incessant increase, monophasic, and biphasic) reflect insulin sensitivity and β-cell function, being worse in the former and superior in the latter. Here, we examined if the OGTT-GRC pattern is worse in obese antibody (glutamic acid decarboxylase 65-kDa [GAD65] and insulinoma-associated protein-2 [IA-2])-positive (Ab

METHODS: Forty-seven obese youth, 15 Ab

RESULTS: Incessant increase OGTT-GRC is the most frequent curve type and is three-fold higher in Ab

CONCLUSION: Severe insulin deficiency, a characteristic of type 1 diabetes, seems to be related to higher prevalence of incessant increase in Ab