Primary Failure of Tooth Eruption: Etiology and Management

Authors

Tetsutaro Yamaguchi
Kazuyoshi Hosomichi
Tatsuo Shirota
Yoichi Miyamoto
Wanida Ono
Noriaki Ono

Publication Date

11-1-2022

Journal

Japanese Dental Science Review

Abstract

Primary failure of eruption (PFE) is a rare disorder defined as incomplete tooth eruption despite the presence of a clear eruption pathway. PFE is known to be caused by rare variants in the parathyroid hormone 1 receptor gene (PTH1R). Although several PTH1R variants have been reported, the etiology of PFE remains unclear. However, important studies that help elucidate the pathology of PFE have recently been published. The purpose of this review is to summarize current treatment options, clinical symptoms or phenotypes for diagnosis, genetic information including solid evidence in mouse disease models and disease-specific induced pluripotent stem cells, thus approaching the etiology of PFE from the perspective of the latest research.

Keywords

Incomplete tooth eruption, Animal model, Disease-specific induced pluripotent stem cells, Treatment

DOI

10.1016/j.jdsr.2022.08.002

PMID

36159186

PMCID

PMC9489741

PubMedCentral® Posted Date

9-15-2022

PubMedCentral® Full Text Version

Post-print

Recommended Citation

Yamaguchi, Tetsutaro; Hosomichi, Kazuyoshi; Shirota, Tatsuo; Miyamoto, Yoichi; Ono, Wanida; and Ono, Noriaki, "Primary Failure of Tooth Eruption: Etiology and Management" (2022). Faculty, Staff and Student Publications. 134.
https://digitalcommons.library.tmc.edu/uthdb_docs/134

Published Open-Access

yes