Faculty, Staff and Student Publications

Publication Date

3-1-2024

Journal

BioEssays

Abstract

Endosteal stem cells are a subclass of bone marrow skeletal stem cell populations that are particularly important for rapid bone formation occurring in growth and regeneration. These stem cells are strategically located near the bone surface in a specialized microenvironment of the endosteal niche. These stem cells are abundant in young stages but eventually depleted and replaced by other stem cell types residing in a non-endosteal perisinusoidal niche. Single-cell molecular profiling and in vivo cell lineage analyses play key roles in discovering endosteal stem cells. Importantly, endosteal stem cells can transform into bone tumor-making cells when deleterious mutations occur in tumor suppressor genes. The emerging hypothesis is that osteoblast-chondrocyte transitional identities confer a special subset of endosteal stromal cells with stem cell-like properties, which may make them susceptible for tumorigenic transformation. Endosteal stem cells are likely to represent an important therapeutic target of bone diseases caused by aberrant bone formation.

Keywords

Humans, Bone Marrow, Osteogenesis, Osteoblasts, Bone Diseases, Stem Cells, Bone Marrow Cells, bone development, bone tumors, single-cell RNA-sequencing, skeletal stem cells

DOI

10.1002/bies.202300173

PMID

38161246

PMCID

PMC11729589

PubMedCentral® Posted Date

1-14-2025

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes

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