Somatic Mutations in Normal Tissues: Calm before the Storm

Authors

Zahraa Rahal
Paul Scheet
Humam Kadara

Publication Date

4-4-2024

Journal

Cancer Discovery

Abstract

We explore the phenomenon of somatic mutations, including those in cancer driver genes, that are present in healthy, normal-appearing tissues and their potential implications for cancer development. We also examine the landscape of these somatic mutations, discuss the role of clonal cell competition and external factors like inflammation in enhancing the fitness of mutant clones, and conclude by considering how understanding these mutations will aid in prevention and/or interception of cancer.

Keywords

Humans, Mutation, Oncogenes, Neoplasms

DOI

10.1158/2159-8290.CD-23-1508

PMID

38571416

PMCID

PMC11234823

PubMedCentral® Posted Date

July 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes