Student and Faculty Publications

Authors

Paul S de Vries
Matthew P Conomos
Kuldeep Singh
Christopher J Nicholson
Deepti Jain
Natalie R Hasbani
Wanlin Jiang
Sujin Lee
Christian L Lino Cardenas
Sharon M Lutz
Doris Wong
Xiuqing Guo
Jie Yao
Erica P Young
Catherine Tcheandjieu
Austin T Hilliard
Joshua C Bis
Lawrence F Bielak
Michael R Brown
Shaila Musharoff
Shoa L Clarke
James G Terry
Nicholette D Palmer
Lisa R Yanek
Huichun Xu
Nancy Heard-Costa
Jennifer Wessel
Margaret Sunitha Selvaraj
Rebecca H Li
Xiao Sun
Adam W Turner
Adrienne M Stilp
Alyna Khan
Anne B Newman
Asif Rasheed
Barry I Freedman
Brian G Kral
Caitlin P McHugh
Chani Hodonsky
Danish Saleheen
David M Herrington
David R Jacobs
Deborah A Nickerson
Eric Boerwinkle
Fei Fei Wang
Gerardo Heiss
Goo Jun
Greg L Kinney
Haakon H Sigurslid
HarshaVardhan Doddapaneni
Ira M Hall
Isabela M Bensenor
Jai Broome
James D Crapo
James G Wilson
Jennifer A Smith
John Blangero
Jose D Vargas
Jose Verdezoto Mosquera
Joshua D Smith
Karine A Viaud-Martinez
Kathleen A Ryan
Kendra A Young
Kent D Taylor
Leslie A Lange
Leslie S Emery
Marcio S Bittencourt
Matthew J Budoff
May E Montasser
Miao Yu
Michael C Mahaney
Mohammed S Mahamdeh
Myriam Fornage
Nora Franceschini
Paulo A Lotufo
Pradeep Natarajan
Quenna Wong
Rasika A Mathias
Richard A Gibbs
Ron Do
Roxana Mehran
Russell P Tracy
Ryan W Kim
Sarah C Nelson
Scott M Damrauer
Sharon L R Kardia
Stephen S Rich
Valentin Fuster
Valerio Napolioni
Wei Zhao
Wenjie Tian
Xianyong Yin
Yuan-I Min
Alisa K Manning
Gina Peloso
Tanika N Kelly
Christopher J O'Donnell
Alanna C Morrison
Joanne E Curran
Warren M Zapol
Donald W Bowden
Lewis C Becker
Adolfo Correa
Braxton D Mitchell
Bruce M Psaty
John Jeffrey Carr
Alexandre C Pereira
Themistocles L Assimes
Nathan O Stitziel
John E Hokanson
Cecelia A Laurie
Jerome I Rotter
Ramachandran S Vasan
Wendy S Post
Patricia A Peyser
Clint L Miller
Rajeev Malhotra

Publication Date

12-1-2023

Journal

Nature Cardiovascular Research

Abstract

Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in 22,400 participants from multiple ancestral groups. We confirmed associations with four known loci and identified two additional loci associated with CAC (ARSE and MMP16), with evidence of significant associations in replication analyses for both novel loci. Functional assays of ARSE and MMP16 in human vascular smooth muscle cells (VSMCs) demonstrate that ARSE is a promoter of VSMC calcification and VSMC phenotype switching from a contractile to a calcifying or osteogenic phenotype. Furthermore, we show that the association of variants near ARSE with reduced CAC is likely explained by reduced ARSE expression with the G allele of enhancer variant rs5982944. Our study highlights ARSE as an important contributor to atherosclerotic vascular calcification, and a potential drug target for vascular calcific disease.

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