Student and Faculty Publications

Publication Date

2-13-2023

Journal

Journal of Chemical Information and Modeling

Abstract

The catalytic function of lysyl hydroxylase-2 (LH2), a member of the Fe(II)/αKG-dependent oxygenase superfamily, is to catalyze the hydroxylation of lysine to hydroxylysine in collagen, resulting in stable hydroxylysine aldehyde-derived collagen cross-links (HLCCs). Reports show that high amounts of LH2 lead to the accumulation of HLCCs, causing fibrosis and specific types of cancer metastasis. Some members of the Fe(II)/αKG-dependent family have also been reported to have intramolecular O

Keywords

Collagen, Ferrous Compounds, Hydroxylysine, Lysine, Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase

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