Student and Faculty Publications
Publication Date
8-1-2023
Journal
Experimental and Clinical Psychopharmacology
Abstract
The behavioral economic measure drug demand and the neural measure late positive potential (LPP) are two measures of motivational value that have been associated with drug relapse risk and treatment outcomes. Despite having overlapping themes, no studies have directly compared drug demand and LPP. Participants (N = 59) included treatment-seeking individuals with cocaine use disorder that had completed both a baseline cocaine demand task and an electroencephalogram (EEG) picture-viewing task of drug-related and pleasant picture cues. Associations between the LPP difference score amplitude (drug-pleasant) and five demand indices (Q₀, essential value [EV], Omax, Pmax, and breakpoint [BP]) were evaluated via Bayesian generalized linear modeling. Positive associations (posterior probabilities ≥ 75%) were found between LPP amplitude and four demand indices (Q₀, EV, Omax, BP). These results suggest that individuals who attach greater relevance to cocaine cues also exhibit greater valuation of cocaine reward. Implications for incorporating methodology from behavioral science and brain imaging are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Keywords
Humans, Cocaine, Cocaine-Related Disorders, Cues, Bayes Theorem, Brain, drug demand, late positive potential, motivational value, cocaine use disorder, electrophysiology
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons, Psychology Commons, Substance Abuse and Addiction Commons
Comments
Trial registration: ClinicalTrials.gov NCT02896712.
Supplementary Materials
PMID: 36480395