Student and Faculty Publications

Publication Date

1-7-2023

Journal

JCO Precision Oncology

Abstract

PURPOSE: Local consolidative therapy (LCT) for patients with synchronous oligometastatic non-small-cell lung cancer is an evolving treatment strategy, but outcomes following LCT stratified by genetic mutations have not been reported. We sought to identify genomic associations with overall survival (OS) and progression-free survival (PFS) for these patients.

METHODS: We identified all patients presenting between 2000 and 2017 with stage IV non-small-cell lung cancer and ≤ 3 synchronous metastatic sites. Patients were grouped according to mutational statuses. Primary outcomes included OS and PFS following initial diagnosis.

RESULTS: Of 194 included patients, 121 received comprehensive LCT to all sites of disease with either surgery or radiation.

CONCLUSION: When compared with wild-type patients, those with

Keywords

Humans, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Benchmarking, Proto-Oncogene Proteins p21(ras), Mutation, ErbB Receptors

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