Faculty, Staff and Student Publications
Publication Date
4-13-2023
Journal
The Journal of Clinical Endocrinology & Metabolism
Abstract
PURPOSE: Pancreatogenic diabetes refers to diabetes mellitus (DM) that develops in the setting of a disease of the exocrine pancreas, including pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). We sought to evaluate whether a blunted nutrient response of pancreatic polypeptide (PP) can differentiate these DM subtypes from type 2 DM (T2DM).
METHODS: Subjects with new-onset DM (<3 >years' duration) in the setting of PDAC (PDAC-DM, n = 28), CP (CP-DM, n = 38), or T2DM (n = 99) completed a standardized mixed meal tolerance test, then serum PP concentrations were subsequently measured at a central laboratory. Two-way comparisons of PP concentrations between groups were performed using Wilcoxon rank-sum test and analysis of covariance while adjusting for age, sex, and body mass index.
RESULTS: The fasting PP concentration was lower in both the PDAC-DM and CP-DM groups than in the T2DM group (P = 0.03 and
CONCLUSIONS: Fasting PP concentrations and the response to meal stimulation are reduced in new-onset DM associated with PDAC or CP compared with T2DM. These findings support further investigations into the use of PP concentrations to characterize pancreatogenic DM and to understand the pathophysiological role in exocrine pancreatic diseases (NCT03460769).
Keywords
Humans, Diabetes Mellitus, Type 2, Pancreatic Polypeptide, Pancreatic Neoplasms, Pancreatitis, Chronic, Carcinoma, Pancreatic Ductal, type 3c diabetes, hormone, biomarker
DOI
10.1210/clinem/dgac670
PMID
36404274
PMCID
PMC10306084
PubMedCentral® Posted Date
November 2022
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
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